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Is Alzheimers Just Another Form of Diabetes? How Our Diet May Be Destroying Our Brains

There is a strong and growing body of evidence showing a link between the dreaded disease and our high sugar consumption.

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8. See the graph in Bijal Trivedi, 1st September 2012. Eat Your Way to Dementia. New Scientist.

9. Johanna Zemva and Markus Schubert, September 2011. Central Insulin and Insulin-Like Growth Factor-1 Signaling – Implications for Diabetes Associated Dementia. Current Diabetes Reviews, Vol.7, No.5, pp356-366. doi.org/10.2174/157339911797415594

10. Eg Weili Xu et al, 2011. Midlife overweight and obesity increase late life dementia risk: a population-based twin study. Neurology, Vol. 76, no. 18, pp.1568–1574.

11. M. Vanhanen et al, 2006. Association of metabolic syndrome with Alzheimer disease: A population-based study. Neurology, vol. 67, pp.843–847.

12. Eric Steen et al, 2005. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes?.
Journal of Alzheimer’s Disease, Vol. 7, pp.63–80.

13. Konrad Talbot et al, 2012. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of Clinical Investigation, Vol.122, No.4, pp.1316–1338. doi:10.1172/JCI59903.

14. Naoki Yamamoto et al, 2012. Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. Journal of Neurochemistry, Vol. 121, 619–628. doi: 10.1111/j.1471-4159.2012.07668.x

15. Eg:
Wei-Qin Zhao and Matthew Townsend, 2009. Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer’s disease.
Biochimica et Biophysica Acta, Vol.1792, pp.482–496. doi.org/10.1016/j.bbadis.2008.10.014,

16. Sónia C. Correia et al, 2011. Insulin-resistant brain state: The culprit in sporadic Alzheimer’s disease? Ageing Research Reviews Vol. 10, 264–273. doi:10.1016/j.arr.2011.01.001

17. T. Ohara et al, 2011. Glucose tolerance status and risk of dementia in the community, the Hisayama study. Neurology, Vol. 77, pp.1126–1134.

18. Karen Neumann et al, 2008. Insulin resistance and Alzheimer’s disease: molecular links & clinical implications. Current Alzheimer Research, Vol.5, no.5, pp438–447.

19. Eg: Lap Ho et al, 2012. Insulin Receptor Expression and Activity in the Brains of
Nondiabetic Sporadic Alzheimer’s Disease Cases. International Journal of Alzheimer’s Disease, Volume 2012. doi:10.1155/2012/321280

20. Suzanne M. de la Monte, 2012. Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease. Drugs, Vol. 72, no.1, pp. 49-66. doi: 10.2165/11597760

21. Ying Liu et al, 2011. Deficient brain insulin signalling pathway in Alzheimer’s disease and diabetes. Journal of Pathology, Vol. 225, pp.54–62. doi: 0.1002/path.2912

22. Konrad Talbot et al, 2012. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. The Journal of Clinical Investigation, Vol.122, No.4, pp.1316–1338. doi:10.1172/JCI59903.

23. http://www.guardian.co.uk/politics/2010/nov/12/government-health-deal-business

24. http://www.guardian.co.uk/society/2012/apr/14/obesity-crisis-doctors-fastfood-deals-ban

25. http://www.guardian.co.uk/business/2012/jun/11/why-our-food-is-making-us-fat

26. http://www.guardian.co.uk/education/2012/sep/10/junk-food-academy-schools-claims

George Monbiot is the author Heat: How to Stop the Planet from Burning. Read more of his writings at Monbiot.com. This article originally appeared in the Guardian.
 
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