Paxil Babies: The Dangers of Antidepressants

By Bruce E. Levine, AlterNet. Posted June 6, 2008.

Today in the United States, 11 percent of women take antidepressants, the use of antidepressants by pregnant women has dramatically increased, and postpartum depression -- rare in those cultures in which women receive high levels of social support following childbirth -- has become so staggeringly common among U.S. women that Congress is legislating increased medical treatment.

Increasing Use of Antidepressants by Pregnant Mothers

Receiving little attention in 2007 was the study "Increasing Use of Antidepressants in Pregnancy," published by the American Journal of Obstetrics and Gynecology. Medical records of 105,335 pregnant women enrolled in Tennessee Medicaid from 1999-2003 revealed that antidepressant use during pregnancy increased from 5.7 percent in 1999 to 13.4 percent in 2003.

Among Tennessee Medicaid-treated women in 2003, 10 percent took antidepressants during the first trimester, 6.4 percent used antidepressants during the second trimester, and 5.9 percent used them during the third. White women were four times more likely than nonwhite women to have used antidepressants during pregnancy, and older women and those with greater schooling were also more likely to have used antidepressants while pregnant.

In another study of pregnant women treated at seven health maintenance organizations (HMOs), American Journal of Obstetrics and Gynecology reported in February 2008 that "antidepressant use in pregnancy nearly quadrupled from 1996 to 2005" and that nearly 8 percent of pregnant women used antidepressants in 2005.

Effect of Antidepressant on Newborns

To the delight of antidepressant manufacturers, the U.S. Centers for Disease Control (CDC) recently told Americans that we need not worry about the effects of Prozac, Paxil, and Zoloft and other antidepressants on newborns. In June 2007, the CDC issued a press release stating "New Study Finds Few Risks of Birth Defects from Antidepressant Use During Pregnancy." CDC epidemiologist Jennita Reefhuis concluded, "Overall, our results are generally reassuring with respect to the use of antidepressants during pregnancy."

This CDC press release was trumpeted by many U.S. newspapers with headlines such as "Antidepressants Not Big Risk for Defects" (Associated Press) and "Reassurance on Antidepressants in Pregnancy" (The Wall Street Journal). However, the actual research findings are the opposite of reassuring.

We have all heard about "crack babies" (newborns addicted to crack cocaine because their mothers were using it during pregnancy). What about "Paxil babies"? In 2006 the Archives of Pediatric & Adolescent Medicine reported that 30 percent of infants who had prenatal exposure to antidepressants experience some withdrawal symptoms, with 13 percent of them experiencing severe ones, most notably tremors, respiratory distress, gastrointestinal problems, sleep disturbances, and high-pitched crying. Other withdrawal symptoms include rapid heart beat, irritability, feeding difficulties, and profuse sweating.

There are several other serious problems that newborns are more likely to suffer when exposed in utero to antidepressants. A 2006 U.S. Food and Drug Administration (FDA) alert stated, "A recently published case-control study has shown that infants born to mothers who took selective serotonin reuptake inhibitors (SSRIs) after the 20th week of pregnancy were 6 times more likely to have persistent pulmonary hypertension (PPHN) than infants born to mothers who did not take antidepressants during pregnancy." In persistent pulmonary hypertension of the newborn, the newborn's arteries to the lungs are constricted, this limiting the amount of blood flow to the lungs and therefore the amount of oxygen into the bloodstream. The FDA alert also noted, "Neonatal PPHN is associated with significant morbidity and mortality."

See more stories tagged with: drugs, antidepressants, pharmaceutical companies, postpartum depression

Bruce E. Levine, Ph.D., is a clinical psychologist and author of Surviving America's Depression Epidemic: How to Find Morale, Energy, and Community in a World Gone Crazy (Chelsea Green Publishing, 2007).

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