Stem Cells and IVF: The Wild West of Reproductive Technology

By Rick Weiss, Science Progress. Posted August 19, 2008.

Americans don't want Uncle Sam slithering between their bed sheets. But recent events in the field of human embryonic stem cell research suggest we'd do well to let the bearded geezer's foot into the bedroom door a tad.

To quote Tom Friedman, "Let me explain."

A few decades ago, the U.S. government was in a position to keep a close eye on, and perhaps even regulate, the fledgling fertility clinic business. Doctors were learning, pretty much by the seat of their pants, how to mix sperm and eggs in laboratory dishes to make human embryos that could then be transferred to the wombs of women who were having trouble getting pregnant.

The technology was a real medical and societal breakthrough. But the decision of how to deal with the newly emerging business of assisted reproductive technology was complicated because the field resided -- and still resides -- in a peculiar regulatory space. To the extent that it constitutes the practice of medicine, it is not subject to federal oversight. But to the extent it constitutes experimentation, it would be subject to a wide array of federal and international rules relating to research on human subjects.

As it turned out, the U.S. government did not want to go there. For one thing, baby-making seemed a very private matter. More importantly, the field was and remains a political hot potato, irrevocably related to the abortion debate and subject to endless sparring among those who do and do not think that microscopic human embryos have the same moral standing as late-stage fetuses or adults. That's relevant because far more embryos are thrown away (or frozen indefinitely in liquid nitrogen) than are turned into babies at in vitro fertilization clinics.

Well, it was one thing for federal overseers to ignore plain vanilla IVF. But of course, things expanded. Today, the number of procedures performed on fertility clinic clients without any good experimental proof of their safety is rather amazing. Over the years, clinics have increasingly turned to intracytoplasmic sperm injection (in which sperm are jammed into an egg, rather than being allowed to fertilize under their own tadpole-like power), with uncertain effects on the recipient egg's chromosomes. Women's eggs have been frozen, then thawed months or years later for fertilization, with virtually no data from animal or human studies to assure that those eggs are not genetically damaged by the process. And increasingly, cells are being plucked for analysis from early embryos before those embryos are transferred to a womb, to test for the presence of various genetic traits. The practice can prevent the birth of children harboring damaging mutations, but could also be used to select embryos with preferred genders or traits. That practice raises ethical concerns about what traits, if any, are appropriate to select for in a child, along with medical concerns about possible developmental effects of the cell-biopsy procedure itself -- none of which, because of the federal government's queasiness, are being adequately addressed.

Finally there are important ethical, economic, and other societal questions that emerge from the related market in sperm and egg "donation," a word that rightly belongs in quotes in this context since altruism is but a small part of the motivation that drives this lucrative industry. Just yesterday, CNN reported disturbing evidence that as a result of the declining economy, a growing number of young women are turning to egg donation as a means of making ends meet -- disturbing not because this is an inherently bad practice but because it is one with real medical and psychological risks and should arguably be played by rules more sensitive than those of unfettered capitalism.

See more stories tagged with: bush, stem cell research, embryo, ivf

Rick Weiss is a Senior Fellow at the Center for American Progress.

Liked this story? Get top stories in your inbox each week from Health and Wellness! Sign up now »