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Why Pot Makes You Feel Good

Explaining the chemistry behind medical marijuana that got Sanjay Gupta and others to finally believe.
 
 
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Last week, CNN’s Dr. Sanjay Gupta  grabbed headlines for coming out in support of the validity of the medical use of marijuana, something he had opposed in the past. What changed his mind? Science.

Here’s what he — and those studying the chemistry of marijuana — now understand.

Marijuana makes chemical contact with human bodies through cannabinoids, which are chemical compounds in marijuana (cannabis). The human body also creates cannabinoids. The body creates cannabinoids on-demand, such as when they are produced to serve as neuroprotectants when the brain’s nerve cells begin to fire too much, as in the case of stress, seizures or an impact to the brain. Our bodies also have cannabinoid receptors. Together, the cannabinoids and their receptors make up the human cannabinoid system.

Just as there was a time when we didn’t know we had immune systems or hormonal systems, until 1988 we didn’t know that we had cannabinoid systems.

The human body produces and utilizes its own cannabinoids, but the body can also utilize cannabinoids from external sources. One source of exogenous cannabinoids is marijuana, or to use marijuana’s botanical name, cannabis. Because these cannabinoids are plant-based, they would be considered  phytocannabinoids. Phytocannabinoids from marijuana fit nicely into human cannabinoid receptors. Thus, the cannabinoids from the cannabis plant can be utilized by the human cannabinoid system.

Any woman who has had a hot flash can find an analogy in the hormone estrogen. As the process of menopause ensues, a woman’s estrogen level drops. Many women seek to balance their hormonal systems by taking in plant-based estrogens, phytoestrogens, such as soy or yams.

Other women, during menopause, seek to balance their hormonal systems through the use of a synthetic estrogen (rather than a plant-based one) such as with the pharmaceutical Premarin.  Likewise, one can take in synthetic cannabinoids through the pharmaceutical Marinol.

So, in this analogy, pot is to a yam what Marinol is to Premarin.

One of the cannabinoids in cannabis – THC (delta-9-tetrahydrocannabinal) — creates a euphoric effect. The other 65 cannabinoids in cannabis do not. CBD (cannabidiol) is another cannabinoid in cannabis. In Gupta’s report, Charlotte Figi, the 6-year-old whose seizures were dramatically reduced by using marijuana, was using a strain of the plant high in CBD. Despite marijuana’s classification as a schedule 1 drug, meaning no medicinal applications, in 2003, the  U.S. federal government patented CBD for medical use. CBD has medicinal applications in conjunction with THC, but also independently of it.

Cannabinoids are generally considered inhibitors. They damp down neurotransmitter release. But this doesn’t mean they necessarily damp down neural activity.  If you inhibit an inhibitor, you get a release.

The big risk with many drugs and pharmaceuticals is respiratory and/or cardiovascular failure. Not so with cannabis. Numerous sources cite the lethal dose of marijuana at 40,000 times greater than the dose it takes to create the euphoric effects.  It may be that there are no fatalities from marijuana use because there are no cannabinoid receptors in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular function.

The human body’s cannabinoid receptors provide places for cannabinoids — human-made, plant-base, or synthetic –  to “plug in.”  The cannabinoid receptor was discovered by Alan Hewitt in 1988. Raphael Mechoulam discovered the first cannabinoid, anandamide, in 1992. Anandamide, a cannabinoid made by the body, affects the same functions as the plant-based cannabinoid THC does: memory, pain, focus, etc.

There is evidence that anandamides are necessary to forget conditioned fear and trauma.Mice engineered to be unable to access their anandamides (cannabinoids produced by their bodies) were unable to get over a negative association to a nonthreatening input, specifically, a tone associated with an electric shock. Even when the electric shock no longer accompanied the stimulus, the mice maintain the conditioned stress response.  Without a functioning cannabinoid system, they were biologically unable to “get over it.”