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Why Marijuana Works Better Than Opiates to Control Pain

It’s all in the way human brains are hardwired.
 
 
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Photo Credit: Shutterstock.com / Iakov Filimonov

 
 
 
 

The following article first appeared in Cannabis Now

One compelling argument for the legalization of  medical marijuana is its ability to ameliorate intense pain. Currently available technologies have helped us gain understanding of cannabis, as well as its more-commonly-accepted  opioid counterparts, and the affects they have on pain.

In 2010, as an attempt to gain insight on pain’s function in the brain, Oxford University conducted a study using fMRI machines and the standard tricks of psychology. Volunteers were monitored during zaps of pain to their feet.

Some areas, they were told, had the potential to be unsafe. In those spots, the volunteers reported their pain levels as being higher. In reality, all of it was safe. Interestingly, in the fMRI machines, the  anterior insula lit up before they were ever zapped. Thinking about, anticipating and fearing pain caused their brains to assume—caused them to feel—the physical sensation of pain.

It’s all in the way human brains are hardwired. The parts of the brain where emotions are processed (the  limbic system) are directly connected to the parts where physical stimuli are detected (the  somatosensory cortex).

This wiring is what gives us the definition of pain, as according to  The International Association for the Study of Pain:  “An unpleasant and emotional experience associated with actual or potential tissue damage.” In essence, it is your brain telling you that somewhere in your body, something is wrong.

Let’s first take a look at the federally recognized, legal remedy for pain: opiates.

As it stands currently, opiates are one of the most commonly prescribed drugs in the United States. This is regardless of the fact that they only have a 30-40 percent success rate for reducing pain. Moreover, 80 percent of the time, they are accompanied by horrible side effects—hormonal imbalance, constipation (often leading to fecal impaction), nausea, and intense drowsiness just to name a few. In order to combat these side effects, patients often have to “take drugs to offset the drugs.”

Although it can be argued that these side effects are relatively small, potentially just inconveniences, the number of people who die from overdoses is not. That is,  125,000 lives in the last decade. The body will build up a tolerance and require higher doses over time, resulting in addiction, illegal drug use and possibly death.

“It started with a snowboarding accident; my knee got really messed up. They had me on  Morphine and OxyContin for a while, but eventually the prescriptions ran out. As soon as they stopped giving me a legitimate source, I got into the underground scene,” says Randall*. “I was pronounced legally dead once, but I still didn’t clean up. My eight-year addiction didn’t stop until it eventually landed me behind bars.”

Cases like Randall’s are not uncommon;  roughly 6 percent of people who take legitimately-prescribed opiates try heroine within ten years.

In 2007, Purdue Pharma (producer of OxyContin) was sued in regards to the built-in time-release OxyContin, which opiate abusers ardently seek. Their marketing led doctors to believe that it had a lower risk of addiction. Abusers discovered they could crush or chew the drug and get the full dose (which is meant to last hours) all at once. Purdue’s defense? They hadn’t advertised to customers, only to doctors. They lost the case and paid $634 million in fines.

Medical cannabis, unlike opiates, doesn’t alleviate pain; it alleviates your emotional response to pain.

Upon observation, it is recognized that higher THC strains do this more effectively. THC is received in your emotional center (the limbic system), which is what causes the relaxation effect.